Sds of 2,6dimethylaniline, safety data sheets, cas 87627. There is also a difference between amine and amides in terms of width and intensity of the peaks. Based on these results, 2, 6 xylidine is classified as a mutagenic carcinogen according to the eu and ghs criteria cat. In addition, the test substance is listed in the clp regulation no 12722008 on classification, labelling and packaging of substances and mixtures and classified as carcinogen cat. A summary of the derivation of the cancer potency and nsrl are also presented. Chemicalbook provide chemical industry users with 2, 6 dimethyl1nitrobenzene boiling point melting point, 2, 6 dimethyl1nitrobenzene density msds formula use,if you also need to 2, 6 dimethyl1nitrobenzene other information,welcome to contact us. We are in the business of phenols and xylenols and their derivatives with manufacturing facilities in india. Male wistar rats were instilled with 10 mg 2, 6 dimethylaniline pure in 10 ml phosphatebuffered saline ph 6 into the intestine. Name last modified size parentdir parent directory. One of the most common mistakes was not to analyze the n ch region correctly to determine what type of compound alkane, alkene, aromatic, or mixed is present. Pharmacopoeial analytical methods for the determination of these impurities are little sensitive. Download hires imagedownload to mspowerpointcite this. The company is registered with indiamart since 8 years. N,ndimethylaniline dma is an organic chemical compound, a substituted derivative of aniline.
Determination of 2,6dimethylaniline and otoluidine. Material safety data sheet secti on 1 2,6dimethylaniline 1 chemical product and company identification msds name. A frequently used synonym for 2, 6 xylidine is 2, 6 dimethylaniline. It is a drug metabolite of lidocaine local anasthetic. It consists of a tertiary amine, featuring dimethylamino group attached to a phenyl group. Commercially significant derivatives are the anesthetics lidocaine, bupivacaine, mepivacaine, and etidocaine. Zn3 ethyl2methyloxazolidin5ylidene2,6dimethylaniline 32 is.
A frequently used synonym for 2,6xylidine is 2,6dimethylaniline. Since free 2, 6 dimethylaniline may be formed by intestinal metabolism of 2, 6 dimethylaniline based azo dyes, its absorption into the circulation from the small intestine was studied. Lidocaine, xylocaine, or lignocaine is a common local anesthetic and antiarrhythmic drug. The 2,6dimethylnitrobenzene is the oxidizing reagent and stannous chloride is used as the reducing reagent in the reaction. Buy high quality 2, 6 dimethylaniline hydrochloride 2143698 6 from toronto research chemicals inc. Buy high quality 2, 6 dimethylaniline 87627 from toronto research chemicals inc. Based on these results, 2,6xylidine is classified as a mutagenic carcinogen according to the eu and ghs criteria cat.
Predicted data is generated using the us environmental protection agencys episuite. The alkaline ph single cell gel electrophoresis scge assay or comet assay was used to evaluate for dna damage induced in bone marrow cells of b6c3f1 mice by four aniline derivatives 2,4dimethylaniline 2,4xylidine. Some of the mimetyperelated functionality in gio requires the. Each step is discussed in more detail in each individual part of. Shut off ignition sources and call fire department. It is used in the production of some anasthetics and other chemicals. It is an important precursor to dyes such as crystal violet preparation and reactions. Commercially significant derivatives are the anesthetics lidocaine, bupivacaine, mepivacaine, and etidocaine production and reactions.
Buy high quality 2,6dimethylaniline 87627 from toronto research chemicals inc. This oily liquid is colourless when pure, but commercial samples are often yellow. Each step is discussed in more detail in each individual part of the lab along with experimental procedures. Dimethylaniline undergoes many of the reactions expected for an aniline, being weakly basic and reactive toward electrophiles. The promoters have expertise of handling hazardous chemicals. When heated to decomposition it emits toxic fumes ofnox.
Date hs code description origin country port of discharge unit quantity value inr per unit inr nov 09 2016. It was found that 2,4 dimethylaniline and 2,4, 6 trimethylaniline were able to damage dna in the liver cells of the. Descriptions of the methodology used in the derivations are provided in the appendix. Many xylidines are prepared by nitration of a xylene followed by hydrogenation of the nitroaromatic, but this. Its cas number is and its smiles structure is nc1cccccc1c. Lu wang, glib baryshnikov, dawei li, hans agren, hiroyuki furuta, yongshu xie. It is used in production of some anesthetics and other chemicals. Dntl was established with the main objective of adding greater value to customers products and realize the potential of innovation.
The glib package contains lowlevel libraries useful for providing data. Import data and price of n n dimethylaniline under hs code. It provides data structure handling for c, portability wrappers, and. Lidocaine is used topically to relieve itching, burning and pain from skin inflammations, injected as a dental anesthetic or as a local anesthetic for minor surgery. Preparation of lidocaine this twostep synthesis involves the following conversion. Alcohols ohstretch usually show a rounded peak in this area.
In this document studies available for cancer doseresponse assessment are provided. Buy high quality 2,6dimethylaniline hydrochloride 21436986 from toronto research chemicals inc. If the spectrum shows a lot of peaks independent from their size. It was found that 2,4dimethylaniline and 2,4,6trimethylaniline were able to damage dna in the liver cells of the. The alkaline ph single cell gel electrophoresis scge assay or comet assay was used to evaluate for dna damage induced in bone marrow cells of b6c3f1 mice by four aniline derivatives 2,4 dimethylaniline 2,4xylidine. The presence of two peaks suggests a primary amine nh 2 while secondary amines show only one peak in this range. Determination of 2,6dimethylaniline and otoluidine impurities in preparations for local anaesthesia by the hplc method with amperometric detection.
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